科研之友
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摘要
We propose a novel approach, based on a Human Leukocyte Antigen (HLA) best-fit criterion, to dynamically allocate live organs (specifically, kidneys) to candidates needing transplantation. A 'reward' is assigned to each level of HLA fit, such that higher rewards are attributed to transplants between better-matched candidates and kidneys. We also envision future technologies by which it will be possible to store organs so that two queues may form: waiting candidates or stored kidneys. Consequently, a double-ended queue of candidates and kidneys is constructed, where the lifetime of a stored kidney is random, and candidates queueing for transplantation may die ('renege') while waiting. We derive expressions for the probability that a candidate gets a kidney before reneging; for the mean numbers of waiting candidates and of stored kidneys; and for a candidate's or kidney's mean sojourn time. Assuming a best-HLA-fit matching policy, we study three measures of effectiveness: (i) Rate of Reward from Transplantation (RRT); (ii) Expected Reward per Transplantation (ERT), calculated as RRT divided by the rate of performed transplantations, and (iii) Gained rate of reward per one dollar of expenditure. The optimal fraction of kidneys that should be stored so as to maximize the rate of reward per one dollar of expenditure is numerically determined.
- 出版日期2018-8
