MULTIFUNCTIONAL DRUGS: MONOAMINE OXIDASE AND alpha-SYNUCLEIN AS TARGETS FOR THE TREATMENT OF PARKINSON%26apos;S DISEASE

作者：Follmer Cristian^*; Bezerra Netto Heleno J C

来源：Quimica Nova, 2013, 36(2): 306-U141.

DOI：10.1590/S0100-40422013000200017

• monoamine oxidase
• alpha-synuclein
• Parkinson%26apos
• s disease

MULTIFUNCTIONAL DRUGS: MONOAMINE OXIDASE AND alpha-SYNUCLEIN AS TARGETS FOR THE TREATMENT OF PARKINSON%26apos;S DISEASE. Parkinson%26apos;s disease (PD) is a neurodegenerative disorder associated to selective degeneration of dopaminergic neurons caused by an intricate relationship among dopamine metabolism, oxidative stress and alpha-synuclein fibrillation. Most therapies for PD have focused on dopamine replacement through the use of both monoamine oxidase inhibitors (MAOIs) and dopamine precursor L-dopa. Interestingly, certain MAOIs have a broad spectrum of action including anti-fibrillogenic properties in alpha-synuclein aggregation. Herein we revisit the chemical properties of MAOIs and their action on important targets associated with PD, notably alpha-synuclein fibrillation and dopamine metabolism, discussing the strategies associated with the development of multi-target drugs for neurodegenerative diseases.

• 出版日期2013