A Convergent Synthesis of Enantiopure Open-Chain, Cyclic, and Fluorinated alpha-Amino Acids

作者:Li Shi Guang; Portela Cubillo Fernando; Zard Samir Z
来源:Organic Letters, 2016, 18(8): 1888-1891.
DOI:10.1021/acs.orglett.6b00656

摘要

A radical based synthesis of a broad variety of protected enantiopure alpha-amino acids, including fluorinated derivatives, is described. The radical addition furnishes naturally latent mercapto-a-amino acids ideally equipped for native chemical ligation.

  • 出版日期2016-4-15