Argyrophilic grain disease: Synergistic component of dementia?

作者：Wallon D^*; Sommervogel C; Laquerriere A; Martinaud O; Lecourtois M; Hannequin D

来源：Revue Neurologique, 2010, 166(4): 428-432.

DOI：10.1016/j.neurol.2009.10.012

• Argyrophilic grain disease
• Dementia
• Alzheimer Disease
• Neuropathology
• Tau
• P62

Introduction. Argyrophilic grain disease (AGD) is one cause of neurodegenerative dementia with a variable clinical spectrum. A neuropathology study is required for diagnosis.
Case report. We report the case of a 68-year-old patient presenting with cognitive decline associating with frontal dysfunction and parkinsonism. Death occurred two years after onset. The neuropathology study revealed a status criblosus in the basal ganglia, neurofibrillary tangles and AGD.
Discussion. We suggest that AGD could explain the atypical course of this dementia considering the fast cognitive decline, the clinical expression and the topography of the lesions.
Conclusion. - This case illustrates the possible synergistic deleterious effect of this pathology on other causes of dementia.

• 出版日期2010-4