科研之友
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摘要
Background: Testosterone is measured for the investigation of female hyperandrogenism and male hypogonadism. Liquid chromatography-tandem mass spectrometry (tandem MS) is becoming the method of choice but comprehensive reference ranges are lacking. %26lt;br%26gt;Methods: Testosterone was measured by tandem MS on 90 healthy women, 67 young healthy men and pregnant women (59 first trimester and 60 second trimester). %26lt;br%26gt;Results: The male, male calculated free, first trimester and second trimester testosterone reference ranges (derived using the antilog of mean +/- 1.96 SD of log transformed data) were 10.6-31.9, 0.23-0.63, 0.6-4.9 and 0.9-4.9 nmol/L, respectively. The female testosterone upper reference range limit, derived non-parametrically from the 97.5th centile, was %26lt;1.7 nmol/L. %26lt;br%26gt;Conclusions: We have derived tandem MS testosterone reference ranges to support clinical services.
- 出版日期2013-3
