Association Between Cerebral Microbleeds and Depression in the General Elderly Population: A Meta-Analysis

作者：Wang, Ruiming; Liu, Keqin; Ye, Xiaoyun; Yan, Shenqiang^*

来源：Frontiers in Psychiatry, 2018, 9: 94.

DOI：10.3389/fpsyt.2018.00094

• depression
• prevalence
• magnetic resonance imaging
• microbleeds
• meta-analysis

Background: It remains unclear whether cerebral microbleeds (CMBs) are associated with depression in the general elderly population. We thus performed a meta-analysis to evaluate the relationship between depression and CMBs. @@@ Methods: A systematic literature search was conducted in EBSCO, PubMed, and Web of Science for relevant studies that assessed the relationship between depression and the prevalence of CMBs. @@@ Results: Five eligible studies including 7,328 patients were pooled in meta-analysis. The prevalence of CMBs was 18.0%. The prevalence of depression was 11.1%. The pooled analysis demonstrated odds ratio for CMBs and depression to be 1.187 (95% confidence interval 1.005-1.403; p = 0.043) with no evidence of statistical heterogeneity (I-2 = 0.0%, p = 0.621). @@@ Conclusion: Our meta-analysis of available published data indicated an increased prevalence of depression in the subjects with pre-existing CMBs. This finding supports the vascular depression hypothesis. Further studies are needed to investigate the role of CMBs in the pathogenesis and progression of depression, which might provide a potential target for the prevention and treatment.

• 出版日期2018-3-19
• 单位浙江大学; 杭州市第一人民医院