Abronione, a rotenoid from the desert annual Abronia villosa

作者：Starks Courtney M^*; Williams Russell B; Norman Vanessa L; Lawrence Julie A; Goering Matt G; O'; Neil Johnson Mark; Hu Jin Feng; Rice Stephanie M; Eldridge Gary R

来源：Phytochemistry Letters, 2011, 4(2): 72-74.

DOI：10.1016/j.phytol.2010.08.004

• Abronia villosa
• Nyctaginaceae
• Rotenoid
• Abronione
• Cytotoxicity

A high-throughput phytochemical investigation of Abronia villosa afforded a new rotenoid designated abronione (1) along with the known compounds boeravinone C and lupeol. The structure of 1 was determined using NMR, MS, and optical analysis with < 400 mu g of material. Compound 1 displayed moderate cytotoxicity against NCI-H460 and HL-60 human cancer cell lines with IC(50) values of 14 and 36 mu M, respectively.

• 出版日期2011-6-15