An economic and efficient tetrahydrofuranylation of alcohols, imines and alkynes

作者：Troisi Luigino^*; Granito Catia; Ronzini Ludovico; Rosato Francesca; Videtta Valeria

来源：Tetrahedron Letters, 2010, 51(46): 5980-5983.

DOI：10.1016/j.tetlet.2010.09.014

• Radical reactions
• Alcohols
• Imines
• Alkynes
• Tetrahydrofuranylation

The tetrahydrofuranyl radical, generated by heating tetrahydrofuran in the presence of air and allyl or benzyl chloride, becomes a useful tool in order to transform the hydroxyl functions into ethers, or the C=N double bond into amine, or the C-C triple bond into vinyl derivatives. A radical mechanism is proposed followed by a nucleophilic substitution for the alcohol substrate and a radical addition for the iminic and the acetylenic reactants.

• 出版日期2010-11-17