Alternative Strategy for Adjusting the Association Specificity of Hydrogen-Bonded Duplexes

作者：Zhang, Penghui; Chu, Hongzhu; Li, Xianghui; Feng, Wen; Deng, Pengchi; Yuan, Lihua^*; Gong, Bing

来源：Organic Letters, 2011, 13(1): 54-57.

DOI：10.1021/ol102522m

• SUPRAMOLECULAR POLYMERS
• MOLECULAR DUPLEXES
• NONCOVALENT SYNTHESIS
• TRIBLOCK COPOLYMERS
• HIGH-STABILITY
• MODEL SYSTEMS
• RECOGNITION
• HETEROCOMPLEX
• FUNCTIONALITY
• HETERODIMER

A strategy for creating new association specificity of hydrogen-bonded duplexes by varying the spacings between neighboring hydrogen bonds is described. Incorporation of naphthalene-based residues has provided oligoamide strands that pair into duplexes sharing the same H-bonding sequences (e.g., DDAA) but differing in the spacings between their intermolecular hydrogen bonds, leading to homo- or heteroduplexes. The ability to manipulate association-specificity as demonstrated by this work may be extended to other multiple hydrogen bonded systems, thereby further enhancing the diversity of multiple hydrogen-bonded association units for constructing supramolecular structures.

• 出版日期2011-1-7
• 单位四川大学