Antituberculosis activity of natural and semisynthetic azorellane and mulinane diterpenoids

作者：Maria Molina Salinas Gloria; Borquez Jorge; Ardiles Alejandro; Said Fernandez Salvador; Alberto Loyola Luis; San Martin Aurelio; Gonzalez Collado Isidro; Manuel Pena Rodriguez Luis

来源：Fitoterapia, 2010, 81(1): 50-54.

DOI：10.1016/j.fitote.2009.07.005

• Azorellane
• Mulinane
• Mycobacterium tuberculosis
• Azorella spp
• Mulinum spp
• Apiaceae

The antituberculosis activity of 14 natural azorellane and mulinane diterpenoids isolated from Azorella compacta, Azorella madreporica, Mulinum crassifolium, and Laretia acaulis, together with eight semisynthetic derivatives, was evaluated against two Mycobacterium tuberculosis strains. The natural azorellanes azorellanol (3) and 17-acetoxy-13-alpha-hydroxyazorellane (6), and the semisynthetic mulinanes 13-hydroxy-mulin-11-en-20-oic-acid methyl ester (13) and mulinenic acid methyl ester (23), showed the strongest activity, with MIC values of 12.5 mu g/mL against both strains. The methylated derivatives 13-hydroxy-mulin-11-en-20-oic-acid methyl ester (13), mulin-11,13-dien-20-oic acid methyl ester (15) and mulinenic acid methyl ester (23) proved to be more active than the parent compounds.

• 出版日期2010-1