Antimicrobial Effect of Chitosan Nanoparticles on Streptococcus mutans Biofilms

作者：de Paz Luis E Chavez^*; Resin Anton; Howard Kenneth A; Sutherland Duncan S; Wejse Peter L

来源：Applied and Environmental Microbiology, 2011, 77(11): 3892-3895.

DOI：10.1128/AEM.02941-10

Nanoparticle complexes were prepared from chitosans of various molecular weights (MW) and degrees of deacetylation (DD). The antimicrobial effect was assessed by the Live/Dead BacLight technique in conjunction with confocal scanning laser microscopy (CSLM) and image analysis. Nanocomplexes prepared from chitosans with high MW showed a low antimicrobial effect (20 to 25% of cells damaged), whereas those prepared from low-MW chitosans showed high antimicrobial effect (>95% of cells damaged).

• 出版日期2011-6