科研之友
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摘要
The transcriptional repressor was first discovered in , where it initially plays a role in gastrulation and mesoderm formation, and later plays a role in neurogenesis. Among arthropods, this role of appears to be conserved in the insects and , but not in the chelicerates and , the myriapod , or the Branchiopod crustacean . These data imply that within arthropoda, acquired its role in gastrulation and mesoderm formation in the insect lineage. However, crustaceans are a diverse group with several major taxa, making analysis of more crustaceans necessary to potentially understand the ancestral role of in Pancrustacea (crustaceans + insects) and thus in the ancestor of insects as well. To address these questions, we examined the family in the Malacostracan crustacean . We found three homologs, , and , and one homolog, . genes are expressed after gastrulation, during germband formation and elongation. , , and are expressed in distinct patterns in the neuroectoderm. is the only gene expressed in the mesoderm, where its expression cycles in the mesodermal stem cells, called mesoteloblasts. The mesoteloblasts go through a series of cycles, where each cycle is composed of a migration phase and a division phase. is expressed during the migration phase, but not during the division phase. We found that as each mesoteloblast division produces one segment's worth of mesoderm, expression is linked to both the cell cycle and the segmental production of mesoderm.
- 出版日期2012-5
