Antimicrobial and antifungal effects of green tea extracts against microorganisms causing vaginitis (Retracted article. See vol. 23, pg. 1005, 2014)

作者：Kim Yong Wan; Chun Heung Jae; Kim In Wook; Liu Hai Bo; Ahn Woong Shick^*

来源：Food Science and Biotechnology, 2013, 22(3): 713-719.

DOI：10.1007/s10068-013-0136-3

• green tea extract
• antimicrobial
• antifungal
• vaginal-related pathogen

Green tea extracts (GTE) including catechins and caffeine possess strong antimicrobial activity against a variety of microorganisms. In this study, we examined their possible antimicrobial and antifungal effects on bacteria (Proteus mirabilis and Streptococcus pyogenes) and yeast species (Candida albicans) that cause vaginitis. The GTE and ethyl acetate fractions exhibited strong growth inhibitory activity against P. mirabilis and S. pyogenes, whereas the aqueous fraction possessed poor antimicrobial activity. Among the catechins, epigallocatechin gallate showed strong antibacterial activity. C. albicans was potently inhibited by the methylene chloride fraction and caffeine, while antifungal activity of GTE was contributed by caffeine. Furthermore, we evaluated whether in vitro activity of GTE included purified solvent fractions that were stable to heat and pH. Antimicrobial activity was potent in alkaline environment for P. mirabilis and acid environment for S. pyogenes and C. albicans. Herein GTE can be a valuable therapeutic agent for the treatment of vaginal-related pathogens.

• 出版日期2013-6
• 单位河北医科大学