Allergy and acute leukaemia in children with Down syndrome: a population study. Report from the Mexican inter-institutional group for the identification of the causes of childhood leukaemia

作者：Nunez Enriquez J C; Fajardo Gutierrez A; Buchan Duran E P; Bernaldez Rios R; Medina Sanson A; Jimenez Hernandez E; Amador Sanchez R; Penaloza Gonzalez J G; Paredes Aguilera R; Alvarez Rodriguez F J; Bolea Murga V; de Diego Flores Chapa J; Flores Lujano J; Bekker Mendez V C; Rivera Luna R; del Carmen Rodriguez Zepeda M; Rangel Lopez A; Dorantes Acosta E M; Nunez Villegas N; Velazquez Avina M M; Torres Nava J R; Reyes Zepeda N C

来源：British Journal of Cancer, 2013, 108(11): 2334-2338.

DOI：10.1038/bjc.2013.237

• acute lymphoblastic leukaemia
• Down syndrome
• allergy
• children
• epidemiology

Background: Allergies have been described as protective factors against the development of childhood acute leukaemia (AL). Our objective was to investigate the associations between allergy history and the development of AL and acute lymphoblastic leukaemia (ALL) in children with Down syndrome (DS).
Methods: A case-control study was performed in Mexico City. The cases (n = 97) were diagnosed at nine public hospitals, and the controls (n = 222) were recruited at institutions for children with DS. Odds ratios (OR) were calculated.
Results: Asthma was positively associated with AL development (OR = 4.18; 95% confidence interval (CI): 1.47-11.87), whereas skin allergies were negatively associated (OR = 0.42; 95% CI: 0.20-0.91).
Conclusion: Our findings suggest that allergies and AL in children with DS share biological and immune mechanisms. To our knowledge, this is the first study reporting associations between allergies and AL in children with DS.

• 出版日期2013-6-11