Association of apolipoprotein M with high-density lipoprotein kinetics in overweight-obese men

作者：Ooi Esther M M; Watts Gerald F; Chan Dick C; Nielsen Lars B; Plomgaard Peter; Dahlback Bjorn; Barrett P Hugh R^*

来源：Atherosclerosis, 2010, 210(1): 326-330.

DOI：10.1016/j.atherosclerosis.2009.11.024

• apoM
• Kinetics
• Obesity
• Metabolic syndrome

Objective: The aim of this study was to investigate associations between plasma apoM concentration and HDL apoA-I and apoA-II kinetics in 60 overweight-obese, insulin resistant men.
Methods: Plasma apoM concentration was determined using a sandwich ELISA with two monoclonal antibodies (CV < 5%). The kinetics of HDL apoA-I and apoA-II were measured using intravenous administration of D(3)-leucine, gas chromatography-mass spectrometry and multi-compartmental modeling.
Results: Plasma apoM was inversely associated with body mass index and positively associated with plasma total cholesterol, LDL cholesterol and HDL cholesterol (p < 0.05). There were no associations between plasma apoM and plasma triglyceride, NEFA, insulin, glucose, HOMA score or adiponectin concentrations. Plasma apoM was positively associated with both apoA-I and apoA-II concentrations (r = 0.406, p < 0.01 and r = 0.510, p < 0.01, respectively) and negatively associated with HDL apoA-I and apoA-II fractional catabolic rate (FCR) (r = -0.291, p = 0.03 and r = -0.291, p = 0.026, respectively). No significant associations were observed between plasma apoM and HDL apoA-I and apoA-II production rate. In multivariate regression models, both plasma apoM and triglycerides were significant, independent predictors of HDL apoA-I FCR (adjusted R(2) = 16%, p < 0.01) and HDL apoA-II FCR (adjusted R(2) = 14%, p < 0.01).
Conclusion: ApoM may be a significant, independent predictor of HDL apoA-I and apoA-II catabolism in overweight-obese, insulin resistant men.

• 出版日期2010-5