A New Sesquiterpene from Nicotiana tabacum and Its Cytotoxicity

作者：Chen Yong Kuan; Meng Chunyang; Su Zhongbi; Wang Lu; Yang Guangyu Yu; Miao Ming Ming^*

来源：Asian Journal of Chemistry, 2014, 26(8): 2246-2248.

DOI：10.14233/ajchem.2014.15680

• Nicotiana tabacum
• Sesquiterpene
• Cytotoxicity
• Tabsesquiterpene A

A new sesquiterpene, tabsesquiterpene A (1) was isolated from the leaves of Nicotiana tabacum. Its structure was elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compound 1 was tested for its cytotoxicity. The results showed that 1 exhibited modest cytotoxicity against SHSY5Y, PC3 and MCF7 with IC50 values of 6.9, 4.5 and 8.8 mu M, respectively.

• 出版日期2014-4
• 单位云南民族大学; 云南省烟草农业科学研究院