Dihydrochalcone glucosides and antioxidant activity from the roots of Anneslea fragrans var. lanceolata

作者：Huang Hung Yi; Ko Horng Huey; Jin Yu Jin; Yang Sheng Zehn; Shih You An; Chen Ih Sheng^*

来源：Phytochemistry, 2012, 78: 120-125.

DOI：10.1016/j.phytochem.2012.02.023

• Anneslea fragrans var. lanceolata Hayata
• Theaceae
• Roots
• Dihydrochalcone glucoside
• Antioxidant activity

Bioassay-guided fractionation of the roots of Anneslea fragrans var. lanceolata led to the isolation of four dihydrochalcone glucosides, davidigenin-2%26apos;-O-(6 %26apos;%26apos;-O-4%26apos;%26apos;%26apos;-hydroxybenzoyl)-beta-glucoside (1), davidigenin-2%26apos;-O-(2 %26apos;%26apos;-O-4%26apos;%26apos;%26apos;-hydroxybenzoy1)-beta-glucoside (2), davidigenin-2%26apos;-O-(3 %26apos;%26apos;-O-4%26apos;%26apos;%26apos;-hydroxybenzoy1)-beta-glucoside (3), and davidigenin-2%26apos;-O-(6 %26apos;%26apos;%26apos;%26apos;-O-syringoy1)-beta-glucoside (4), and beta known compounds. The structures were identified by means of spectroscopic analysis. Davidigenin-2%26apos;-O-(6 %26apos;%26apos;-O-syringoyl)-beta-glucoside (4), 1-O-3,4-dimethoxy-5-hydroxy phenyl-6-O-(3,5-di-O-methylgalloyl)-O-glucopyranoside (5), lyoniresinol (10), and syringic acid (13) showed ABTS [2,2%26apos;-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid)] cation radical scavenging activity, with SC50 values of 52.6 +/- 5.5, 26.0 +/- 0.7, 6.0 +/- 0.2, and 27.5 +/- 0.6 mu g/mL in 20 min, respectively. Lyoniresinol (10), isofraxidin (12), and syringic acid (13) also showed DPPH [1,1-dipheny1-2-picrylhydrazyl] radical scavenging activity, with SC50 values of 8.4 +/- 1.8, 51.6 +/- 2.2, and 4.3 +/- 0.7 mu g/mL in 30 min, respectively.

• 出版日期2012-6