Decreased aEEG Continuity and Baseline Variability in the First 48 Hours of Life Associated With Poor Short-Term Outcome in Neonates Born Before 29 Weeks Gestation

作者：Bowen Jennifer R^*; Paradisis Mary; Shah Dharmesh

来源：Pediatric Research, 2010, 67(5): 538-544.

Amplitude-integrated electroencephalography (aEEG) provides us with a method of assessing brain activity in critically ill neonates. In extremely premature neonates, the aEEG trace is predominantly discontinuous, making it difficult to distinguish between a "normal" and "abnormal" trace. We measured aEEG activity in the first 48 h of life in neonates born before 29-wk gestation and used both visual and quantitative analysis of the aEEG data to assess differences in neonates with poor short-term outcome [death or peri/intraventricular hemorrhage (P/IVH)] compared with those who survived without P/IVH to identify features of an abnormal aEEG. On quantitative analysis, EEG continuity <80% at 10-mu V level was a sensitive and specific marker of poor short-term outcome. By using this marker, we identified 83% of neonates who died or developed grade 3 or 4 IVH and 60% of neonates who developed grades 1 or 2 IVH, with a positive predictive value for death or any IVH of 73% and a negative predictive value of 86%. Absence of sleep-wake cycling with baseline variability <2 mu V was the strongest predictor of outcome using visual analysis alone. (Pediatr Res 67: 538-544,2010)

• 出版日期2010-5