摘要

A concise one-pot 3-step cascade reaction to biologically significant imidazo[1,2-alpha]heterocycles is described. The methodology utilizes acetyl cyanide as a non-classical isocyanide replacement for TMSCN in a microwave-assisted [4+1] cycloaddition (the Groebke-Bienayme-Blackburn reaction) followed by a Strecker reaction under catalysis free conditions. The methodology proceeds with operational simplicity, short reaction times, and high bond forming efficiency.

  • 出版日期2015-2-18