Neonatal Alloimmune Thrombocytopenia Associated with Massive Chronic Intervillositis: A Case Report and Review of the Literature

作者：Tchakarov Amanda^*; Coffey Amy; Tatevian Nina

来源：Pediatric and Developmental Pathology, 2013, 16(1): 32-34.

DOI：10.2350/12-08-1246-CR.1

• maternal antibodies
• placental alloimmunization
• platelet destruction

Neonatal alloimmune thrombocytopenia (NAIT) presents as isolated thrombocytopenia in a normal neonate as a result of destruction of fetal platelets by maternal antibodies against paternally derived human platelet antigens. Neonatal alloimmune thrombocytopenia affects 0.1% of births, with maternal antibodies crossing the placenta as early as 14 weeks' gestation. Few reports describe placental histopathological changes occurring in NAIT cases. We present a case of NAIT associated with massive chronic intervillositis, a rare entity occurring in 0.06% to 0.8% of reviewed 2nd- and 3rd-trimester placentas; to our knowledge, this is the 1st report of such an association.

• 出版日期2013-2