Attempt to Synthesize 2,3,5,4 '-Tetrahydroxystilbene Derived from 2,3,5,4 '-Tetrahydroxystilbene-2-O-beta-glucoside (THSG)

作者：Tamura Masafumi^*; Koshibe Yuhei; Kaji Kiho; Ueda Jun ya; Shirataki Yoshiaki

来源：Chemical & Pharmaceutical Bulletin, 2015, 63(2): 122-125.

DOI：10.1248/cpb.c14-00626

• Polygonum multiflorum
• Mizoroki-Heck reaction
• 2-aryl-2,3-dihydrobenzofuran
• 2,3,5,4 '-tetrahydroxystilbene-2-O-beta-glucoside (THSG)

An attempt to synthesize aglycone 1 derived from 2,3,5,4'-tetrahydroxystilbene-2-O-beta-glucoside (THSG) via the Wittig reaction and Mizoroki-Heck reaction is described. In the Wittig protocol, 2,3,5,4'-tetramethoxystilbene 2 was obtained. Additionally, a palladium-catalyzed Mizoroki- Heck reaction strategy yielded 2-aryl-2,3-dihydrobenzofuran 13 instead of derivative 12 in good yield.

• 出版日期2015-2