Application of beta-Cyclodextrin Modified Mseoporous Spherical Particles of Mesoporous Silicate as the Substrate for Chiral High Performance Liquid Chromatography

作者：Chen Sheng Wen; Bing Nai Ci; Li Qing Hua^*

来源：Chinese Journal of Analytical Chemistry, 2008, 36(9): 1249-1252.

• Spherical particles of mesoporous silicate
• 3-Glycidoxypropytrimethoxysilane
• beta-cyclodextrin
• chiral separation
• fixed phase

Spherical particles of mesoporous silicate (SBA15) with average pore size of 3.5 nm and particle size of 4.3 mu m have been synthesized. Puronics P123 (EO20PO70EO20) and cetyltrimethylammonium bromide (CTMAB) were used as surfactant and co-surfactant. beta-Cyclodextrin was grafted within the channel of mesoporous silica SBA15 by means of KH560 SBA15 was characterized by XRD, FT-IR, SEM, Micromeritics ASAP and thermogravimetry-differential scanning catorimetry (TG-DSC). The functionalized SBA15 was packed in a steel column and applied in chiral HPLC to separate chiral chemicals. Results show that Dns-Phe and chiral drugs lbuprofen were successfully separated on the column packed with SBA15 fuctionalized with beta-cyclodextrin.

• 出版日期2008-9
• 单位上海第二工业大学