An Increased Frequency in HLA Class I Alleles and Haplotypes Suggests Genetic Susceptibility to Influenza A (H1N1) 2009 Pandemic: A Case-Control Study

作者：Falfan Valencia Ramces; Narayanankutty Arun; Resendiz Hernandez Juan M; Perez Rubio Gloria; Ramirez Venegas Alejandra; Nava Quiroz Karol J; Bautista Felix Nora E; Vargas Alarcon Gilberto; Castillejos Lopez Manuel D J; Hernandez Andres

来源：Journal of Immunology Research, 2018, 2018: 3174868.

DOI：10.1155/2018/3174868

<jats:p><jats:italic>Background</jats:italic>. The influenza A H1N1/09 pandemic infected a small number of exposed individuals, which suggests the involvement of genetic factors. There are scarce data available on classical HLA class I association with the influenza A H1N1/09 pandemic. <jats:italic>Methods</jats:italic>. We analyzed the frequency of classical HLA class I alleles and haplotypes in A H1N1/09 influenza in a case-control study including 138 influenza patients (INF-P) and 225 asymptomatic healthy contacts (INF-C) simultaneously recruited. HLA class I typing was performed by high-resolution sequence-based typing method. <jats:italic>Results</jats:italic>. Our analysis revealed higher frequency of C<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mo>∗</mml:mo></mml:math>07:02:01, B<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mo>∗</mml:mo></mml:math>39:06:02, C<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M3"><mml:mo>∗</mml:mo></mml:math>03:02:01, B<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M4"><mml:mo>∗</mml:mo></mml:math>44:03:01, B<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M5"><mml:mo>∗</mml:mo></mml:math>51:01:05, and B<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M6"><mml:mo>∗</mml:mo></mml:math>73:01 (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M7"><mml:mi>p</mml:mi><mml:mo>&lt;</mml:mo><mml:mn>0.05</mml:mn></mml:math>; OR = 1.84–9.98) and of two haplotypes—A<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M8"><mml:mo>∗</mml:mo></mml:math>68:01:02-C<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M9"><mml:mo>∗</mml:mo></mml:math>07:02:01 (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M10"><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>1.05</mml:mn><mml:mi>E</mml:mi><mml:mo>−</mml:mo><mml:mn>05</mml:mn></mml:math>; OR = 23.99) and B<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M11"><mml:mo>∗</mml:mo></mml:math>35:01:01-C<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M12"><mml:mo>∗</mml:mo></mml:math>07:02.01 (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M13"><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>4.15</mml:mn><mml:mi>E</mml:mi><mml:mo>−</mml:mo><mml:mn>04</mml:mn></mml:math>, OR = 2.15)—in A H1N1/09 influenza subjects. A<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M14"><mml:mo>∗</mml:mo></mml:math>68:01:01 was exclusively present only in the INF-P group (5/138). A decrease in the frequency of C<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M15"><mml:mo>∗</mml:mo></mml:math>03:03:01, A<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M16"><mml:mo>∗</mml:mo></mml:math>11:01:01, B<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M17"><mml:mo>∗</mml:mo></mml:math>39:01:01, A<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M18"><mml:mo>∗</mml:mo></mml:math>24:02:01, C<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M19"><mml:mo>∗</mml:mo></mml:math>03:04:01, B<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M20"><mml:mo>∗</mml:mo></mml:math>51:01:01, and C<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M21"><mml:mo>∗</mml:mo></mml:math>07:01:01 (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M22"><mml:mi>p</mml:mi><mml:mo>&lt;</mml:mo><mml:mn>0.05</mml:mn></mml:math>; OR = 0.12–0.52) and of haplotypes A<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M23"><mml:mo>∗</mml:mo></mml:math>02:01:01-B<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M24"><mml:mo>∗</mml:mo></mml:math>35:01:01-C<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M25"><mml:mo>∗</mml:mo></mml:math>04:01:01, A<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M26"><mml:mo>∗</mml:mo></mml:math>24:02:01-B<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M27"><mml:mo>∗</mml:mo></mml:math>35:01:01, B<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M28"><mml:mo>∗</mml:mo></mml:math>39:01:01-C<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M29"><mml:mo>∗</mml:mo></mml:math>07:02:01, and B<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M30"><mml:mo>∗</mml:mo></mml:math>40:02:01-C<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M31"><mml:mo>∗</mml:mo></mml:math>03:04:01 (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M32"><mml:mi>p</mml:mi><mml:mo>&lt;</mml:mo><mml:mn>0.05</mml:mn></mml:math>; OR = 0.08–0.22) were observed in INF-P group. <jats:italic>Conclusion</jats:italic>. Selective classical HLA class I allele and haplotype combinations predispose individuals towards susceptibility or protection against the influenza A H1N1/09 pandemic. This work has significant implications for accessing population transmission risk for A H1N1/09 or a similar strain breakout in the future.</jats:p>

• 出版日期2018