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摘要
A new 2,3-seco-12-oleanene-2,3-dioic acid (1), along with ten known ones, was isolated from the bark of Aglaia perviridis. Their structures were elucidated on the basis of spectroscopic data. Compound 1 was evaluated for its cytotoxic activities in human cancer cell lines K562 (human leukemia), SMMC-7721 (hepatocellular carcinoma), MCF-7 (breast cancer), and KB (oral epithelium cancer) and drug-resistant cells of MCF-7/ADM, and KB/VCR, and for its anti-inflammatory activities in lipopolysaccharide-stimulated RAW264.7 macrophages. Compound 1 was found to be the most potent inhibitor of nitrite production in macrophages, with IC50 value at 6.5 mu M.
- 出版日期2016-5
- 单位河南大学
