Diterpenoids and phenylethanoid glycosides from the roots of Clerodendrum bungei and their inhibitory effects against angiotensin converting enzyme and alpha-glucosidase

作者：Liu, Qing; Hu, Hai-Jun; Li, Peng-Fei; Yang, Ying-Bo; Wu, Li-Hong; Chou, Gui-Xin; Wang, Zheng-Tao^*

来源：Phytochemistry, 2014, 103: 196-202.

DOI：10.1016/j.phytochem.2014.02.015

• Clerodendrum bungei
• Lamiaceae
• Chemistry of Chinese medicines
• Diterpenoid
• Phenylethanoid glycoside
• Angiotensin converting enzyme
• alpha-Glucosidase

Abietane derivatives, bungnates A, B, 15-dehydrocyrtophyllone A and 15-dehydro-17-hydroxycyrtophyl-lone A, and two phenylethanoid glycosides, bunginoside A and 3 '',4 ''-di-O-acetylmartynoside, together with nine known abietane derivatives and fourteen known phenylethanoid glycosides, were isolated from dried roots of Clerodendrum bungei. Their structures were determined on the basis of detailed spectroscopic analyses and acidic hydrolysis. The absolute configuration of bunginoside A was established from analysis of CD data. Selected compounds were evaluated for inhibitory effects against angiotensin converting enzyme (ACE) and alpha-glucosidase. 15-Dehydrocyrtophyllone A showed an ACE inhibitory effect, and verbascoside, leucosceptoside A and isoacteoside exhibited strong inhibitory capacity against alpha-glucosidase.

• 出版日期2014-7
• 单位上海中药标准化研究中心; 中国药科大学; 上海中医药大学