Development and characterization of 5 canine B-cell lymphoma cell lines

作者：Zwingenberger Allison L^*; Vernau William; Shi Changying; Yan Wensheng; Chen Xinbin; Gordon Ira K; Kent Michael S

来源：Leukemia Research, 2012, 36(5): 601-606.

DOI：10.1016/j.leukres.2011.11.004

• Canine
• B-cell lymphoma
• Cell line
• Non-Hodgkin's

Canine and human lymphoma share similar characteristics in disease development and response to therapy. Translational research can be furthered using tools such as canine cell lines to model therapeutic compounds and strategies. We developed 5 B-cell lymphoma cell lines from dogs with confirmed large B-cell lymphoma. These cell lines were CD3, CD18, CD20, and CD90 positive with variable CD79a, CD1c and CD34 expression. All cell lines were tumorigenic in Nu/nu mice and were wild type for p53. Canine lymphoma cell lines serve as an important resource for translational lymphoma research.

• 出版日期2012-5
• 单位NIH