Disparities in lipid control and statin drug use among diabetics with noncoronary atherosclerotic vascular disease vs those with coronary artery disease

作者：Thapa Rashmi; Sharma Suresh; Jeevanantham Vinodh; Hu Casper; Myers Taylor; Vacek James L; Dawn Buddhadeb; Gupta Kamal^*

来源：Journal of Clinical Lipidology, 2015, 9(2): 241-246.

DOI：10.1016/j.jacl.2014.11.006

• Diabetes mellitus
• Noncoronary atherosclerotic vascular disease
• Lipids
• Statin
• Peripheral arterial disease
• Carotid stenosis
• Abdominal aortic aneurysm

BACKGROUND: Diabetes mellitus (DM), coronary artery disease (CAD), and noncoronary atherosclerotic vascular diseases (NCVDs) have similar risks of cardiovascular events and similar recommendations for lipid control. There are limited data regarding lipid control in diabetic patients with NCVD in current clinical practice.
OBJECTIVE: To assess current day practice of lipid control in patients with DM with NCVD vs those with CAD.
METHODS: We retrospectively identified 3336 patients with DM and known atherosclerotic vascular disease between January 2009 and March 2012. We compared demographic variables, lipid levels, and statin use in diabetics with CAD alone vs diabetics without CAD but with one or more NCVD.
RESULTS: There were 234 patients in DM with NCVD group and 3102 patients in DM with CAD group. The DM with NCVD group had a higher mean total cholesterol (152 +/- 40 vs 146 +/- 42 mg/dL; P = .019) and mean low-density lipoprotein (LDL; 86 +/- 35 vs 80 +/- 34 mg/dL; P = .04) with only 70% of patients achieving LDL of <100 mg/dL (compared with 80% in the DM with CAD group; P < .001). Statin use was 100% in CAD vs 75% in NCVD group (P < .001). In addition to limited use of more potent statins in the NCVD group, there was also a significantly lower dose of statins used overall.
CONCLUSION: Our study demonstrates lower use and less aggressive application of statins among diabetics with NCVD compared with diabetics with CAD, resulting in higher mean LDL and total cholesterol in the NCVD group.

• 出版日期2015-4