Assessment of myocardial repolarisation parameters in patients with familial Mediterranean fever

作者：Karaman Kayihan^*; Karayakali Metin; Erken Ertugrul; Demirtas Ahmet; Ozturk Mustafa; Altunkas Fatih; Arisoy Arif; Turan Oguzhan Ekrem; Ceyhan Koksal; Celik Atac

来源：Cardiovascular Journal of Africa, 2017, 28(3): 154-158.

DOI：10.5830/CVJA-2016-074

• familial Mediterranean fever
• myocardial repolarisation
• cTp-Te interval
• cTp-Te/QT ratio

Background: Familial Mediterranean fever (FMF) is a chronic, recurrent auto-inflammatory disease characterised by self-terminating attacks of fever and sterile polyserositis. The main cause of death in auto-inflammatory diseases is cardiovascular events. Additionally, auto-inflammatory diseases have potential effects on the myocardial repolarisation parameters, including the T-wave peak-to-end (Tp-Te) interval, cTp-Te interval (corrected Tp-Te) and the cTp-Te/QT ratio. The aim of this study was to analyse the efficacy of myocardial repolarisation alterations in anticipation of cardiovascular risks in patients with FMF.
Methods: This study included 66 patients with FMF and 58 healthy control subjects. Tp-Te and cTp-Te intervals and the cTp-Te/QT ratio were measured from the 12-lead electrocardiogram.
Results: In electrocardiographic parameters, analysis of QT, QT dispersion, corrected QT (QTc) and QTc dispersion were similar between the groups. The Tp-Te and cTp-Te intervals and Tp-Te/QT and cTp-Te/QT ratios were significantly prolonged in FMF patients. Multivariate linear regression analyses indicated that erythrocyte sedimentation rate was an independent predictor of a prolonged cTp-Te interval.
Conclusions: Our study revealed that when compared with control subjects, Tp-Te and cTp-Te intervals and cTp-Te/QT ratio were increased in FMF patients.

• 出版日期2017-5