Antibacterial thymol derivatives isolated from Centipeda minima

作者：Liang Hengxing; Bao Fukai; Dong Xiaoping; Tan Rui; Zhang Caijun; Lu Qing; Cheng Yongxian^*

来源：Molecules, 2007, 12(8): 1606-1613.

DOI：10.3390/12081606

• Centipeda minima
• Compositae
• thymol derivatives
• antibacterial activity

Two new monoterpenoids, 8,10-dihydroxy-9(2)-methylbutyryloxythymol (1) and 10-hydroxy-8,9-dioxyisopropylidene-thymol (2), together with five known thymol derivatives: 8,9,10-trihydroxythymol (3), thymol-beta-glucopyranoside (4), 9-hydroxythymol (5), 8,10-dihydroxy-9-isobutyryloxythymol (6), and 8-hydroxy-9,10-diisobutyryl-oxythymol (7), were isolated from Centipeda minima. Their structures were identified by means of spectroscopic analyses. Interestingly, compound 2 is not an extraction artifact according to a close HPLC examination of material after extraction by analytical MeOH at ambient temperature. The antibacterial activities of compounds 1-7 were evaluated against eight microbial strains by the agar dilution method.

• 出版日期2007-8
• 单位成都中医药大学; 中国科学院昆明植物研究所; 西南交通大学; 昆明医科大学