New efficient synthesis of 1H-pyrimido[2,1-b]quinazoline-2, 6-diones via a tandem aza-Wittig/nucleophilic addition/intramolecular cyclization/isomerization reaction starting from the Baylis-Hillman adducts

作者：Yuan, Ding; Kong, Han-Han; Ding, Ming-Wu^*

来源：Tetrahedron, 2015, 71(3): 419-423.

DOI：10.1016/j.tet.2014.12.006

• 1H-Pyrimido[2,1-b]quinazoline-2,6-dione
• Aza-Wittig reaction
• Baylis-Hillman reaction
• Nucleophilic addition
• Isomerization

Iminophosphoranes 3, obtained from the Baylis-Hillman adducts, reacted with 2-azidobenzoyl chloride to give the azides 4. The sequential reaction of azides 4 with triphenylphosphine and isocyanate produced 1H-pyrimido[2,1-b]quinazoline-2,6-diones 9 in the presence of sodium ethoxide via a tandem aza-Wittig/nucleophilic addition/intramolecular cyclization/isomerization reaction.

• 出版日期2015-1-21
• 单位华中师范大学