NF-κB的信号通路与阻断策略

作者：邢飞跃; 赵克森; 姜勇

来源：中国病理生理杂志, 2003, 19(06): 129-135.

DOI：10.3321/j.issn:1000-4718.2003.06.039

• NF-KappaB
• 信号转导
• 炎症
• 肿瘤

NF-κB is thought of as a genetic switch to control expressions of many target genes and directly participates in pathogenesis of infection, inflammation, stress, immunoresponse, cellular apoptosis, toxic shock and tumor as well as cell-cycle regulation and cell differentiation. The overactivation of NF-κB is intimately involved in many human diseases. Various therapeutic strategies against NF-κB, to date, include anti-inflammatory drugs, antioxidants, immunosuppressive agents, inhibitors of protease and proteasome, prostaglandings, nitric oxide, IL-10, microbial products, synthetic inhibitors, antisense oligonucleotides and decoy deoxyoligonucleotides. Studies are underway to develop NF-κB member-specific and cell type-specific drugs that can inhibit the activation of NF-κB only in target cells and that may become a novel way to treat the human diseases.

• 出版日期2003
• 单位南方医科大学