Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma In Situ, Metastatic Tumor Deposits and Areas for Further Research

作者：Hendry Shona; Salgado Roberto; Gevaert Thomas; Russell Prudence A; John Tom; Thapa Bibhusal; Christie Michael; van de Vijver Koen; Estrada M V; Gonzalez Ericsson Paula I; Sanders Melinda; Solomon Benjamin sss; Solinas Cinzia; Van den Eynden Gert G G M; Allory Yves; Preusser Matthias; Hainfellner Johannes; Pruneri Giancarlo; Vingiani Andrea; Demaria Sandra; Symmans Fraser; Nuciforo Paolo; Comerma Laura; Thompson E A; Lakhani Sunil; Kim Seong Rim; Schnitt Stuart

来源：Advances in Anatomic Pathology, 2017, 24(5): 235-251.

DOI：10.1097/PAP.0000000000000162

• lymphocytes
• tumor-infiltrating
• biomarkers
• cancer
• immunotherapy
• pathology

Assessment of tumor-infiltrating lymphocytes (TILs) in histopathologic specimens can provide important prognostic information in diverse solid tumor types, and may also be of value in predicting response to treatments. However, implementation as a routine clinical biomarker has not yet been achieved. As successful use of immune checkpoint inhibitors and other forms of immunotherapy become a clinical reality, the need for widely applicable, accessible, and reliable immunooncology biomarkers is clear. In part 1 of this review we briefly discuss the host immune response to tumors and different approaches to TIL assessment. We propose a standardized methodology to assess TILs in solid tumors on hematoxylin and eosin sections, in both primary and metastatic settings, based on the International Immuno-Oncology Biomarker Working Group guidelines for TIL assessment in invasive breast carcinoma. A review of the literature regarding the value of TIL assessment in different solid tumor types follows in part 2. The method we propose is reproducible, affordable, easily applied, and has demonstrated prognostic and predictive significance in invasive breast carcinoma. This standardized methodology may be used as a reference against which other methods are compared, and should be evaluated for clinical validity and utility. Standardization of TIL assessment will help to improve consistency and reproducibility in this field, enrich both the quality and quantity of comparable evidence, and help to thoroughly evaluate the utility of TILs assessment in this era of immunotherapy.

• 出版日期2017-9
• 单位河北医科大学