A pH-responsive hydrogel with potent antibacterial activity against both aerobic and anaerobic pathogens

作者：Hu, Jingjing; Zheng, Zhao; Liu, Cenxi; Hu, Qianyu; Cai, Xiaopan; Xiao, Jianru; Cheng, Yiyun^*

来源：Biomaterials Science, 2019, 7(2): 581-584.

DOI：10.1039/c8bm01211c

• GRAPHENE OXIDE
• POLYMERS
• BACTERIA
• NANOPARTICLES
• INFECTION
• RELEASE
• GROWTH
• PO2

Aminoglycosides are a family of antibiotics with a wide-spread antibacterial spectrum and high antibacterial activity. However, they are less effective against anaerobic pathogens due to the requirement of aerobic respiration to exert their antibacterial functions. Here, we prepared a pH-responsive hydrogel with potent antibacterial activities against both aerobic and anaerobic pathogens. The hydrogel was prepared by reacting oxidized dextran with aminoglycoside and an ornidazole analogue via an acid-labile Schiff base linkage. The prepared hydrogel was injectable, self-healing, biocompatible, and showed a pH-responsive drug release behavior. More importantly, the gel was efficient in killing both aerobic and anaerobic pathogens. This study provides a facile strategy to expand the antibacterial spectrum of aminoglycoside hydrogels.

• 出版日期2019-2-1
• 单位天津市中医药研究院附属医院; 华东师范大学; 中国人民解放军第二军医大学; 华南理工大学