Advances in biotechnological production of 1,3-propanediol

作者：Kaur Guneet; Srivastava A K^*; Chand Subhash

来源：Biochemical Engineering Journal, 2012, 64: 106-118.

DOI：10.1016/j.bej.2012.03.002

• Glycerol
• 1,3-propanediol
• Bioprocess design
• Modelling
• Polytrimethylene terephthalate
• Downstream processing

1,3-propanediol (1,3-PD) is a chemical compound with myriad applications particularly as a monomer for the production of polyesters, polyethers and polyurethanes. It is a raw material for the production of biodegradable plastics, films, solvents, adhesives, detergents, cosmetics and medicines. Various strategies have been employed for the microbial production of 1,3-PD which include several bioprocess cultivation techniques facilitated by natural and/or genetically engineered microbes. Though 1,3-PD is produced in nature by the bioconversion of glycerol its production directly from sugars like glucose has been also made possible by the development of recombinant strains. This review presents the %26quot;state of the art%26quot; in the biotechnological production technologies of 1,3-PD particularly with respect to bioprocess engineering methods. It also highlights the significance of mathematical model-based approach for designing various bioreactor operating strategies to facilitate the improvement in 1,3-PD production. Attempt has also been made to focus on the protocols used for downstream processing of 1,3-PD and the associated problems. Finally concluding remarks on the future outlook on biobased 1,3-PD to reduce the dependence on disappearing fossil fuels are presented.

• 出版日期2012-5-15