Does aprotinin preserve platelets in children with acyanogenic congenital heart disease undergone surgery with cardiopulmonary bypass?

作者：Ferreira Cesar Augusto^*; de Andrade Vicente Walter Villela; Barbosa Evora Paulo Roberto; Rodrigues Alfredo Jose; Klamt Jyrson Guilherme; de Carvalho Panzeli Carlotti Ana Paula; Carmona Fabio; Manso Paulo Henrique

来源：Brazilian Journal of Cardiovascular Surgery, 2009, 24(3): 373-381.

• Extracorporeal membrane oxygenation
• Aprotinin
• Hemostasis
• Blood platelets
• Cardiovascular surgical procedures

Objective: Evaluation of the hemostatic and platelets effects in children with acyanogenic congenital heart disease undergone on-pump surgery who received aprotinin.
Methods: A prospective randomized study was performed on children aged 30 days to 4 years who had undergone correction of acyanogenic congenital heart disease using cardiopulmonary bypass (CPB) and were divided into two groups: Control (n=9) and Aprotinin (n=10). In the Aprotinin Group the drug was administered before and during CPB and the hemostatic dysfunction was analyzed by clinical and biochemical markers. Differences were considered to be significant when P<0.05.
Results: The groups were similar regarding demographic and intraoperative variables, except for a greater hemodilution in the Aprotinin Group. The drug presented no benefit regarding time of mechanical pulmonary ventilation, stay in the postoperative intensive care unit and hospital, or regarding the use of inotropic drugs and renal function. Platelet concentration was preserved with the use of Aprotinin, whereas thrombocytopenia occurred in the Control Group since the initiation of CPB. Blood loss was similar for both groups. There were no complications with the use of Aprotinin.
Conclusion: Aprotinin quantitatively preserved the blood platelets in children with acyanogenic congenital heart disease.

• 出版日期2009-9