Musculoskeletal changes after 1 year of exercise in older breast cancer survivors

作者：Dobek Jessica^*; Winters Stone KerriM; Bennett Jill A; Nail Lillian

来源：Journal of Cancer Survivorship, 2014, 8(2): 304-311.

DOI：10.1007/s11764-013-0313-7

• Follow-up
• Resistance exercise
• Bone density
• Muscle strength
• Neoplasms
• Older adult

Introduction We have previously reported that 1 year of supervised resistance+impact training stopped bone loss and built muscle strength in older breast cancer survivors. The purpose of this study was to determine whether these benefits persisted 1 year after completion of the intervention. %26lt;br%26gt;Methods Sixty-seven women from the original trial completed baseline and post-intervention body composition and muscle strength tests, and 44 women were available 1 year later for follow-up assessments. Bone mineral density (grams per square centimeter) of the hip and spine, muscle mass (kilograms), and fat mass (kilograms) were measured by dual-energy X-ray absorptiometry and maximal upper and lower body strength were measured by one-repetition maximum tests (kilograms). We compared between group changes across baseline (preintervention), 1 (post-intervention), and 2 years (1 year follow up) on study outcomes using repeated-measures analysis of covariance, adjusting for age. %26lt;br%26gt;Results Significant group by time interactions were found for spine bone mineral density (BMD) (p %26lt; 0.01) and lower body muscle strength (p %26lt; 0.05), with a trend for upper body muscle strength (p = 0.05). Spine BMD remained stable across intervention and follow-up periods in exercisers compared with continuous losses in controls across 1-and 2-year periods. In contrast, lower body strength increased in exercisers across the intervention, but decreased to near-baseline levels during follow-up compared with no change over either time period in controls. %26lt;br%26gt;Conclusions Our data suggest that spine BMD can be preserved in older breast cancer survivors even after formal exercise training stops; however, muscle strength is not similarly maintained and may require continued participation in a supervised exercise program. %26lt;br%26gt;Implications for Cancer Survivors Exercise programs aimed at improving musculoskeletal health should be considered in the long-term care plan for breast cancer survivors.

• 出版日期2014-6