Acute effects of traditional Japanese alcohol beverages on blood glucose and polysomnography levels in healthy subjects

作者：Kido Megumi; Asakawa Akihiro; Koyama Ken Ichiro K; Takaoka Toshio; Tajima Aya; Takaoka Shigeru; Yoshizaki Yumiko; Okutsu Kayu; Takamine Kazunori T; Sameshima Yoshihiro; Inui Akio^*

来源：PeerJ, 2016, 4: e1853.

DOI：10.7711/peerj.1853

• Sake
• Shochu
• Alcohol
• Postprandial glucose levels
• Insulin levels
• Tipsiness
• Koji

Background. Alcohol consumption is a lifestyle factor associated with type 2 diabetes. relationship is reportedly different depending on the type of alcohol beverage The purpose of this study was to examine the acute effects of traditional Japanese alcohol beverages on biochemical parameters, physical and emotional state, land sleep patterns
Methods. Six healthy subjects (three men and three women; age, 28.8 +/- 9.5 years; body mass index, 21.4 +/- 1.6 kg/m(2)) consumed three different types of alcohol beverages (beer, shochu, and sake, each with 40 g ethanol) or mineral water with dinner on different days in the hospital. Blood samples were collected before and 1, 2, and 12 h after drinking each beverage, and assessments of physical and emotional state were administered at the same time. lIn addition, sleep patterns and brain waves were examined using polysomnography.
Results. Blood glucose levels at 1 h and the 12-h area under the curve (AUC) value after drinking shochu were significantly lower than that with water and beer. The 12-h blood insulin AUC value after drinking shochu was significantly lower than that with beer. Blood glucose x insulin level atl 1 h and the 2-h blood glucose x insulin AUC value with shochu were significantly lower than that with beer. The insulinogenic indexes at 2 h with beer and sake, but not shochu, were significantly higher than that with water. The visual analogue scale scores of physical and emotional state showed that the tipsiness levels with beer, shochu, and sake at 1 h were significantly higher than that with water. These tipsiness levels were maintained at 2 h. The polysomnography showed that the rapid eye movement (REM) sleep latency with shochu and sake were shorter than that with water and beer.
Conclusions. Acute consumption of alcohol beverages with a meal resulted in different responses in postprandial glucose and insulin levels as well as REM sleep latency. Alcohol beverage type should be taken into consideration for people with impaired glucose tolerance.

• 出版日期2016-4-4