A novel ratiometric fluorescent H2S probe based on tandem nucleophilic substitution/cyclization reaction and its bioimaging

作者：Kang, Jin; Huo, Fangjun^*; Yin, Caixia^*

来源：Dyes and Pigments, 2017, 146: 287-292.

DOI：10.1016/j.dyepig.2017.07.016

• Fluorescence probe
• Endogenous HS-
• Ratiometric

The third gasotransmitter hydrogen sulfide (H2S) plays a vital role to human health and diseases. A water-soluble ratiometric fluorescent probe (HS-1) for hydrogen sulfide (H2S) has been developed, which resulted in an increase of the emission at 403 nm along with a concomitant decrease of fluorescence peak at 519 nm, the ratios of emission intensities at 403 and 519 nm (I-403/I-519) displayed an increase from 0.27 to 8.54. This probe showed excellent selectivity toward H2S over other common anions and bio-thiols. Furthermore, these successes of intracellular imaging experiments in A549 cells indicated that this probe is suitable for imaging of ex-/endogenous hydrogen sulfide in living cells.

• 出版日期2017-11
• 单位山西大学; 中国科学院长春应用化学研究所