Asymmetric Total Synthesis and Structural Elucidation of NFAT-68

作者：Wang, Lin; Xi, Yumeng; Yang, Shouliang; Zhu, Rong; Liang, Yufan; Chen, Jiahua^*; Yang, Zhen

来源：Organic Letters, 2011, 13(1): 74-77.

DOI：10.1021/ol102574d

• 1ST TOTAL-SYNTHESIS
• BIOSYNTHESIS
• INHIBITOR
• ACID

Total synthesis of NFAT-68 (7) has been achieved and its relative stereochemistry has been determined. A key step thereof is the utilization of the chelation-controlled vinylogous Mukaiyama aldol reaction (VMAR) to stereoselectively synthesize the sytt-aldol product 8. This developed chemistry is anticipated to have wider application in total syntheses of many other natural products.

• 出版日期2011-1-7
• 单位北京大学