Macrophage colony stimulating factor: Not just for macrophages anymore! A gateway into complex biologies

作者：Douglass Thomas G; Driggers Lara; Zhang Jian Gang; Hoa Neil; Delgado Christina; Williams Christopher C; Dan Qinhong; Sanchez Ramon; Jeffes Edward W B; Wepsic H Terry; Myers Michael P; Koths Kirston; Jadus Martin R^*

来源：International Immunopharmacology, 2008, 8(10): 1354-1376.

DOI：10.1016/j.intimp.2008.04.016

• macrophage colony stimulating factor
• cytokine
• tumor

Macrophage colony stimulating factor (M-CSF, also called colony stimulating factor-1) has traditionally been viewed as a growth/differentiation factor for monocytes, macrophages, and some female-specific tumors. As a result of alternative mRNA splicing and post-translational processing, several forms of M-CSF protein are produced: a secreted gtycoprotein, a longer secreted form containing proteoglycan, and a short membrane-bound isoform. These different forms of M-CSF all initiate cell signaling in cells bearing the M-CSF receptor, called c-fms. Here we review the biology of M-CSF, which has important roles in bone physiology, the intestinal tract, cancer metastases to the bone, macrophage-mediated tumor cell killing and tumor immunity. Although this review concentrates mostly on the membrane form of human M-CSF (mM-CSF), the biology of the soluble forms and the M-CSF receptor will also be discussed for comparative purposes. The mechanisms of the biological effects of the membrane-bound M-CSF reveal that this cytokine is unexpectedly involved in many complex molecular events. Recent experiments suggest that a tumor vaccine based on membrane-bound M-CSF-transduced tumor cells, combined with anti-angiogenic therapy, should be evaluated further for use in clinical trials.

• 出版日期2008-10