Discovery and SAR of a novel series of non-MPEP site mGlu(5) PAMs based on an aryl glycine sulfonamide scaffold

作者：Rodriguez Alice L; Zhou Ya; Williams Richard; Weaver C David; Vinson Paige N; Dawson Eric S; Steckler Thomas; Lavreysen Hilde; Mackie Claire; Bartolome Jose M; Macdonald Gregor J; Daniels J Scott; Niswender Colleen M; Jones Carrie K; Conn P Jeffrey; Lindsley Craig W; Stauffer Shaun R^*

来源：Bioorganic & Medicinal Chemistry Letters, 2012, 22(24): 7388-7392.

DOI：10.1016/j.bmcl.2012.10.068

• Metabotropic glutamate receptor 5 (mGlu(5))
• Positive allosteric modulator (PAM)
• Non-MPEP

Herein we report the discovery and SAR of a novel series of non-MPEP site metabotropic glutamate receptor 5 (mGlu(5)) positive allosteric modulators (PAMs) based on an aryl glycine sulfonamide scaffold. This series represents a rare non-MPEP site mGlu(5) PAM chemotype.

• 出版日期2012-12-15