Association of 5HTTLPR gene polymorphisms with bipolar disorder and affective temperaments

作者：Yuan C M^*; Yu S Y; Li Z Z; Huang J; Hong W; Qian Y P; Fang Y R

来源：Journal of Shanghai Jiaotong University(Medical Science), 2011, 31(11): 1518-1522.

DOI：10.3969/j.issn.1674-8115.2011.11.003

• Affective temperament
• Bipolar disorder
• Gene polymorphism
• Paris and San Diego-autoquestionnaire version
• Pisa
• Serotonin transporter gene-linked polymorphic region
• Temperament Evaluation of Memphis

Objective To explore the association of serotonin transporter gene-linked polymorphic region (5-HTTLPR) gene polymorphisms with bipolar disorder and affective temperaments. Methods Case-control design was adopted, and 305 patients with bipolar disorder and 272 normal controls were enrolled. Temperament Evaluation of Memphis, Pisa, Paris and San Diego-autoquestionnaire version (TEMPS-A) was employed to assess the affective temperaments. Chi-square test, T test, nonparametric test and ANOVA were used to explore the association of 5-HTTLPR gene polymorphisms with bipolar disorder and affective temperaments. Results 5-HTTLPR L/S polymorphisms were associated with bipolar disorder in females (genotype, χ2 = 6.769, P =0.034; allele, χ2 = 6.028, P = 0.014), S allele of 5-HTTLPR L/S polymorphisms was associated with anxious temperament of patients with bipolar disorder (t = 8.248, P = 0.005), and LA allele of 5-HTTLPR rs25531 A/G polymorphisms was associated with hyperthymic temperament of patients with bipolar disorder (Z = -2.205, P =0.027). Conclusion 5-HTTLPR gene polymorphisms are associated with the prevalence of bipolar disorder in females, which can also regulate the affective temperaments of patients with bipolar disorder in some degree.

• 出版日期2011
• 单位上海交通大学