A new triterpenoid from Brucea javanica

作者：Liu, Jian Hua; Qin, Jiang Jiang; Jin, Hui Zi^*; Hu, Xiao Jia; Chen, Ming; Shen, Yun Heng; Yan, Shi Kai; Zhang, Wei Dong

来源：Archives of Pharmacal Research, 2009, 32(5): 661-666.

DOI：10.1007/s12272-009-1503-8

• Brucea javanica
• Triterpenoid
• Bruceajavanin C
• NO production

A new triterpenoid, bruceajavanin C (1), together with bruceosides A and B (2 and 3), bruceines D and E (4 and 5), yadanziosides A and G (6 and 7), (20R)-O-(3)-alpha-L-arabinopyranosylpregn-5-ene-3 beta,20-diol (8), and alpha-D-glucopyranoside, (3 beta, 20R)-3-hydroxypregn-5-en-20-yl (9) were isolated from the aerial parts of Brucea javanica. The structure of 1 was elucidated on the basis of 2D-NMR spectroscopic analysis. In addition, compounds 1, 3, 4, 5, and 6 exhibited mild inhibitory effect on NO production in LPS-stimulated RAW264.7 cells.

• 出版日期2009-5
• 单位上海交通大学; 中国人民解放军第二军医大学