A straightforward synthesis of pyrimido[4,5-b]quinoline derivatives assisted by microwave irradiation

作者：Quiroga Jairo^*; Trilleras Jorge; Insuasty Braulio; Abonia Rodrigo; Nogueras Manuel; Marchal Antonio; Cobo Justo

来源：Tetrahedron Letters, 2010, 51(7): 1107-1109.

DOI：10.1016/j.tetlet.2009.12.114

• Pyrimido[4,5-b]quinolines
• Deazaflavins
• Cyclization
• Microondas irradiation

Several pyrimido[4,5-b]quinolines, flavin analogues, have been prepared by assisted microwave intramolecular cyclization of N(4)-substituted-2,4-diamino-6-chloropyrimidine-5-carbaldehydes. The reaction takes place with hydrolysis of amino-group and chlorine. Particularly valuable features of this method included the broader substrate scope and operational simplicity as well as increased safety for small-scale high-speed synthesis.

• 出版日期2010-2-17