Mass-count plots for crystal size control

作者：Griffin Daniel J; Grover Martha A; Kawajiri Yoshiaki; Rousseau Ronald W

来源：Chemical Engineering Science, 2015, 137: 338-351.

DOI：10.1016/j.ces.2015.06.048

• Crystal size control
• Process analytic technology
• Mass-count plot
• ATR-FTIR
• FBRM

We present measurements from batch crystallization as a trajectory in the phase space mapped out by the crystal mass and the total chord count. This new perspective yields a framework for monitoring and controlling crystallization that has two beneficial attributes: first, crystallization is seen as movement we find that this fosters an intuitive understanding of crystallization kinetics; and, second, the problem of controlling the average crystal size is cast as a trajectory-endpoint control problem-we find that this promotes the development of spatially-oriented control schemes.
The utility of the proposed framework is demonstrated by application. In particular, we apply the framework to: 1) elucidate the effects of simple temperature manipulations on the crystallization kinetics; 2) interpret the actions applied by supersaturation control (SSC) and direct nucleation control (DNC) to produce large crystals; and 3) develop a control scheme-termed spatially-guided action trajectory endpoint control (sGATEC)-that can be applied to produce crystals of pre-selected average size.

• 出版日期2015-12-1