Multicenter Case Series of Indolent Small/Medium-Sized CD8(+) Lymphoid Proliferations With Predilection for the Ear and Face

作者：Li Janet Y; Guitart Joan; Pulitzer Melissa P; Subtil Antonio; Sundram Uma; Kim Youn; Deonizio Janyana; Myskowski Patricia L; Moskowitz Alison; Horwitz Steven; Querfeld Christiane^*

来源：American Journal of Dermatopathology, 2014, 36(5): 402-408.

DOI：10.1097/DAD.0b013e3182a74c7a

• CD8(+) lymphoma
• indolent
• cytotoxic granules
• low proliferation index
• ear
• face

We report 7 cases of a CD8(+) lymphoid proliferation of the ear and face with a cytotoxic T-cell phenotype, but an indolent clinical course. All patients presented with stable or slowly growing asymptomatic lesions on the ear, nose, or lower eyelid. Histopathology showed a dense diffuse dermal infiltrate of small- to medium-sized atypical lymphocytes without destructive features. The lymphocytes were positive for CD3, CD8, -F1, and TIA-1 and negative for CD4, CD30, CD56, granzyme B, and PD-1. Of note, the proliferation index was low in available cases. All patients remained in complete remission at median follow-up of 14 months regardless of treatment modality. Staging was negative for extracutaneous disease in all patients. The clinically indolent behavior and histopathologic phenotype together with a low proliferation index (10%-15%) emphasize the importance of accurate diagnosis and appropriate clinical management to avoid overtreatment and complications of therapy.

• 出版日期2014-5
• 单位西北大学