A randomized trial of platelet transfusions over 30 vs 120 minutes: is there an effect on post-transfusion platelet counts?

作者：Dannaway D C^*; Noori S

来源：Journal of Perinatology, 2013, 33(9): 703-706.

DOI：10.1038/jp.2013.46

• thrombocytopenia
• platelet
• transfusion
• necrotizing enterocolitis
• sepsis

OBJECTIVE: To determine whether platelet infusion time affects platelet counts in thrombocytopenic newborns. %26lt;br%26gt;STUDY DESIGN: This was a prospective randomized control study of 43 platelet transfusions given to newborns. Transfusions were randomized to run over either 30 min or 2 h. Platelet counts taken 30 min and 6 h after transfusion were compared using parametric, nonparametric, Pearson%26apos;s correlation and logistic regression. %26lt;br%26gt;RESULT: Changes in platelet counts 30 min and 6 h after transfusion were not different between the groups. Weak but significant negative correlations existed between postmenstrual age and change in platelet count at 30 min (r = -0.33, P = 0.04) and 6 h (r = -0.37, P = 0.018) after transfusion. There were no differences between the mean blood pressures before and after transfusion in either group. %26lt;br%26gt;CONCLUSION: Transfusion duration does not affect post-transfusion platelet counts in newborns. Babies of lower postmenstrual age (PMA) may have better responses to platelet transfusions. Finally, platelet transfusions over both durations are well tolerated in neonates.

• 出版日期2013-9