A Metal- and Azide-Free Multicomponent Assembly toward Regioselective Construction of 1,5-Disubstituted 1,2,3-Triazoles

作者：Wan, Jie-Ping^*; Cao, Shuo; Liu, Yunyun

来源：Journal of Organic Chemistry, 2015, 80(18): 9028-9033.

DOI：10.1021/acs.joc.5b01121

• RHODIUM-CATALYZED TRANSANNULATION
• ONE-POT SYNTHESIS
• ALKYNE CYCLOADDITION
• TERMINAL ALKYNES
• 1,3-DIPOLAR CYCLOADDITION
• ORGANIC AZIDES
• 1,4-DISUBSTITUTED 1,2,3-TRIAZOLES
• REGIOSPECIFIC SYNTHESIS
• EFFICIENT SYNTHESIS
• TRIAZOLE FORMATION

The construction of 1,5-disubstituted 1,2,3-triazoles has been effected through the cascade dual C-N bond formation, N-N bond formation and an acyl migration-based C-C bond formation via the three-component reactions of enaminones, tosylhydrazine and primary amines. This metal- and azide-free, regioselective synthetic method proceeds in the presence of only molecular iodine.

• 出版日期2015-9-18
• 单位江西师范大学