Diastereoselective synthesis of beta-aminosulfones from the 1,2-addition to N-(para-methoxyphenyl) imines

作者：Anderson James C^*; Campbell Ian B; Campos Sebastien; Shannon Jonathan

来源：Tetrahedron Letters, 2014, 55(52): 7206-7208.

DOI：10.1016/j.tetlet.2014.11.017

• beta-Aminosulfone
• Imine
• Sulfone
• Diastereoselective
• 1,2-addition

The base-promoted 1,2-addition of alkyl phenylsulfones to N-(para-methoxyphenyl) imines was investigated as a direct route to stereochemically defined beta-aminosulfones. Using (BuLi)-Bu-n as base, 2-(phenylsulfonyl)ethylbenzene was added to a range of N-(para-methoxyphenyl) imines to give B-aminosulfone products in high yields as single anti-diastereoisomers. Other less substituted alkyl phenylsulfones were not as successful.

• 出版日期2014-12-24