A novel amalgamation of 1,2,3-triazoles, piperidines and thieno pyridine rings and evaluation of their antifungal activity

作者：Darandale Sunil N; Mulla Nayeem A; Pansare Dattatraya N; Sangshetti Jaiprakash N; Shinde Devanand B^*

来源：European Journal of Medicinal Chemistry, 2013, 65: 527-532.

DOI：10.1016/j.ejmech.2013.04.045

• 1,2,3-triazole
• Thieno pyridine
• Piperazine and antifungal activity

It is the first report of the novel amalgamation of 1,2,3-triazoles, piperidines, thieno pyridine rings and evaluation of their antifungal activity. The synthesized compounds showed interesting moderate to good antifungal activity, wherein they were able to discriminate between the two species Aspergillus flavus and Aspergillus niger of the same genus. In addition, the main highlight of this series is the sensitivity of the fungal strain Gyptococcus neoformans to the compounds having p-chlorobenzoyl (9h), methane sulfonyl (9i) and p-methylbenzene sulfonyl (9j) attached to the piperazine nitrogen.

• 出版日期2013-7